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Kunihiko Morihiro, Ph.D.

E-mail: morihiro(at)chembio.t.u-tokyo.ac.jp

Japanese CV / English CV

Education

  1. B.S.; Department of Pharmaceutical Sciences, Osaka University, 2008
  2. M.S.; Graduate School of Pharmaceutical Sciences, Osaka University, 2010
  3. Ph.D.; Graduate School of Pharmaceutical Sciences, Osaka University, 2013

Appointments

  1. JSPS Research Fellow (DC1); 2010-2013
  2. Postdoctral Fellow at National Institute of Biomedical Innovation (NIBIO); 2013-2015
  3. JSPS Postdoctral Fellow for Research Abroad at the University of Pittsburgh; 2015-2017
  4. Assistant Professor at Department of Chemistry and Biotechnology, The University of Tokyo; 2017-2024
  5. Associate Professor at Department of Chemistry and Biotechnology, The University of Tokyo; 2024-present

Representative Publications

  1. “Selective Inhibition of Cancer Cell Migration Using a pH-Responsive Nucleobase-Modified DNA Aptamer”
    Yuyuan Chen, Kunihiko Morihiro* (co-first author), Yui Nemoto, Akito Ichimura, Ryosuke Ueki, Shinsuke Sando, Akimitsu Okamoto*
    Chem. Sci. 2024, 15, 17097-17102.
  2. “RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality”
    Kunihiko Morihiro*, Shunto Morita, Naoki Harada, Manami Baba, Jongmin Yum, Mitsuru Naito, Kanjiro Miyata, Genta Nagae, Akimitsu Okamoto*
    J. Am. Chem. Soc. 2024, 146, 1346-1355.
  3. “Nucleic Acid-to-Small Molecule Converter through Amplified Hairpin DNA Circuits”
    Kunihiko Morihiro*, Yasuhiro Tomida, Daisuke Fukui, Manami Hasegawa, Akimitsu Okamoto*
    Angew. Chem. Int. Ed. 2023, 62, e202306587.
  4. “Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly”
    Kunihiko Morihiro*, Hiraki Osumi, Shunto Morita, Takara Hattori, Manami Baba, Naoki Harada, Riuko Ohashi, Akimitsu Okamoto*
    J. Am. Chem. Soc. 2023, 145, 135-142.
  5. “Identification of Nucleobase Chemical Modifications that Reduce the Hepatotoxicity of Gapmer Antisense Oligonucleotides”
    Tokuyuki Yoshida, Kunihiko Morihiro (co-first author), Yuki Naito, Atsushi Mikami, Yuuya Kasahara, Takao Inoue*, Satoshi Obika*
    Nucleic Acids Res. 2022, 50, 7224-7234.
  6. “anti-syn Unnatural Base Pair Enables Alphabet-Expanded DNA Self-Assembly”
    Kunihiko Morihiro, Yuya Moriyama, Yui Nemoto, Hiraki Osumi, Akimitsu Okamoto*
    J. Am. Chem. Soc. 2021, 143, 14207-14217.
  7. “Floxuridine Oligomers Activated under Hypoxic Environment”
    Kunihiko Morihiro, Takuro Ishinabe, Masako Takatsu, Hiraki Osumi, Tsuyoshi Osawa, Akimitsu Okamoto*
    J. Am. Chem. Soc. 2021, 143, 3340-3347.
  8. “Hydrogen Peroxide-Triggered Gene Silencing in Mammalian Cells through Boronated Antisense Oligonucleotides”
    Shohei Mori, Kunihiko Morihiro*, Takumi Okuda, Yuuya Kasahara, Satoshi Obika*
    Chem. Sci. 2018, 9, 1112-1118.
  9. “Small Molecule Release and Activation through DNA Computing”
    Kunihiko Morihiro, Nicholas Ankenbruck, Bradley Lukasak, Alexander Deiters*
    J. Am. Chem. Soc. 2017, 139, 13909-13915.
  10. “Light-Triggered Strand Exchange Reaction Using the Change in the Hydrogen Bonding Pattern of a Nucleobase Analogue”
    Kunihiko Morihiro, Tetsuya Kodama, Reiko Waki, Satoshi Obika*
    Chem. Sci. 2014, 5, 744-750.
  11. “Selenomethylene Locked Nucleic Acid Enables Reversible Hybridization in Response to Redox Changes”
    Kunihiko Morihiro, Tetsuya Kodama, Kentefu, Yoshihiro Moai, Rakesh N. Veedu, Satoshi Obika*
    Angew. Chem. Int. Ed. 2013, 52, 5074-5078.