Our Targets
We are studying on chemistry and life science of
nucleic acid methylation/demethylation using new chemical probes
intracellular RNA behavior using special chemical probes
chromatins consisting of chemically synthesized DNA and histones
single-cell functions through trapping and release of special cells
chemical protection from protein aggregation
aggregation of functional oligonucleotides in a cell
nucleic acid delivery through chemical functionalization
proto-nucleic acids built under prebiotic environments
How are our bodies created from atoms and molecules? We systematically investigate how the atoms and building blocks of biopolymers (nucleic acids and proteins) participate in biological phenomena, introducing synthetic chemistry-based ideas into biological and genetic studies. Research in our group is concerned with diverse aspects of the design and function of biopolymers on an atomic scale. The focus is on the design, synthesis and physical properties of new, man-made biopolymers with various special functions. Also included is the design of unprecedented organic chemical systems for recognizing, transforming and visualizing a single component or atom in biopolymers of interest. These researches are the fundamental studies reflecting the essence of life science on an atomic scale and the material-developing studies to get useful functional materials for the latest studies on life sciences and medical technologies. The lab employs a multidisciplinary approach involving organic synthesis, photophysical chemistry, state-of-the-art spectroscopy, and biological assays to address new approaches to the interface between synthetic chemistry and life science. Current projects include:
- Synthesis of ‘superbiopolymers’ containing functional nucleotides and amino acids for elucidation of gene expression function.
- Construction of new chemical platforms for collecting specific cells and analyzing cell-cell interactions at the single cell level.
- Drug design, cell introduction, and functional analysis based on new chemical ideas.
- Chemical exploration of ‘proto-nucleic acids’ under prebiotic conditions.
Collection of Works
- Nucleic acid medicinehttps://doi.org/10.1021/jacs.2c08974
- Chemical synthesis of proteinshttps://doi.org/10.1039/D1SC00731A
- Single cell-cell communicationhttps://doi.org/10.1021/jacs.2c07321
- Peptide ligation activatorshttps://doi.org/10.1039/C9SC00646J
- Anchored cell membrane sheetshttps://doi.org/10.1021/acsabm.0c00583
- Sensing of a ‘genome lifetime’ controllerhttps://doi.org/10.1002/cbic.201900555
- Origin of ribosehttps://doi.org/10.1039/C7OB02051A
- Metallic sensing of DNA epigeneticshttps://doi.org/10.1021/jacs.6b06428
- Nucleic acid medicine
https://doi.org/10.1021/jacs.2c08974 - Chemical synthesis of proteins
https://doi.org/10.1039/D1SC00731A - Single cell-cell communication
https://doi.org/10.1021/jacs.2c07321 - Peptide ligation activators
https://doi.org/10.1039/C9SC00646J - Anchored cell membrane sheets
https://doi.org/10.1021/acsabm.0c00583 - Sensing of a ‘genome lifetime’ controller
https://doi.org/10.1002/cbic.201900555 - Origin of ribose
https://doi.org/10.1039/C7OB02051A - Metallic sensing of DNA epigenetics
https://doi.org/10.1021/jacs.6b06428
Research Category List
Bioorganic Chemistry | Organic Synthesis | Nucleic Acid Chemistry | Chemical Protein Engineering | Cell Immobilization | |
In-Cell Organic Chemistry | Live Cell Imaging | Epigenetics | Cell interaction | Raman Spectroscopy | |
Origin of Life | Photodynamic Therapy | Dye design |
Bioorganic Chemistry
Organic Synthesis
Nucleic Acid Chemistry
Chemical Protein Engineering
Cell Immobilization
In-Cell Organic Chemistry
Live Cell Imaging
Epigenetics
Cell interaction
Raman Spectroscopy
Origin of Life
Photodynamic Therapy
Dye design
How to join us
Department of Chemistry and Biotechnology (MS/PhD integrated program)
To enroll in the Graduate School of Engineering as a graduate student, you are required to successfully pass an entrance examination.
See the website of the Department of Chemistry and Biotechnology.
http://www.chembio.t.u-tokyo.ac.jp/e/exam.html
Okamoto laboratory strongly encourages you to take the exam of the MS/PhD integrated program. First of all, please contact Okamoto after checking Okamoto’s papers.
Department of Advanced Interdisciplinary Studies (PhD course, no course for master degree)
The course provides mid-career persons with the opportunity to carry out doctoral studies in the university environment. Before requesting application forms, you are advised to contact the department office and inquire whether you can find an appropriate supervisor. If you want to join the Okamoto laboratory, then you also contact Okamoto by e-mail.
See the website of the Graduate School of Engineering, the University of Tokyo
Application for PostDoc position
- Contact Okamoto by e-mail
Contact Okamoto by an email with your CV. If there are some openings in the lab, you would receive an email for the next process. - Apply to the postdoctoral fellowship programs of the Japan Society for the Promotion of Science (JSPS) Contact Okamoto by an email with your CV before preparing the application form. You can find some information on the JSPS postdoctoral fellowship for foreign researchers in the
Members
Yuki Umeda
DC●■
Yijing Lin
DC●‡
Yuyuan Chen
DC●
Taiki Uno
DC●‡■
Xueyang Li
DC●‡■
Xuanyu Liao
DC●‡■
Yunsong Xu
DC●‡
Zihao Wang
DC●‡¶
Sijie Li
DC●
Soshu Yasuda
DC●‡¶■
Ryotaro Yamamoto
DC●■
Huize Zhang
DC●■
Manami Baba
M2●
Naoki Harada
M2●
Jotaro Miyamoto
M2●
Bumkyu Choi
M2●‡
Xiping Wang
M2●
Tamako Aiba
M1●
Shuichiro Koga
M1●
Ryota Shinohara
M1●
Chiharu Moriyama
M1●
Hiroki Oiwa
B4●
Aoba Okuta
B4●
Tento Sugiura
B4●
Kei Fujita
B4●
Keisuke Horikoshi
B4●
Moeko Yamada
B4●
Xi Weng
Research Student●
Chie Shishido
Secretary
Hiroki Tanigami
Technical Staff
Eriko Yamada
Technical Staff
Mizue Yuuki
Technical Staff
●Department of Chemistry and Biotechnology / ●Department of Advanced Interdisciplinary Studies / JSPS Research Fellowship for Young Scientists / ■Spring-GX / ¶MERIT-WINGS / ‡Integrated MS/PhD Program (Department of Chemistry and Biotechnology) / ◆JICA-Friendship Project
Class Information
講義「分子集合体化学」(CH3323L1)担当:岡本 晃充 教授
講義資料:分子集合体化学(1)配布用; 分子集合体化学(3)配布用
講義「生命化学演習」(FEN-CB3m07S1)担当:長尾 翌手可 講師
講義資料:第1回_化学平衡; 第2回 酵素反応速度論
バーチャル先端研公開 2020
DNAオリガミ(小)折り方
DNAオリガミ(小)型紙
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Building 5 of the School of Engineering, 7th Floor
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
4 minutes on foot from Todaimae, Namboku Line
10 minutes on foot from Hongo-sanchome, Marunouchi Line / Oedo Line
12 minutes on foot from Nezu, Chiyoda Line
Phone: +81-3-5841-8702 (Office), +81-3-5841-6536 (Laboratory)
E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp
郵便物宛先
〒113-8656 東京都文京区本郷7-3-1
東京大学 大学院工学系研究科 化学生命工学専攻
岡本研究室
宅急便宛先
〒113-8656 東京都文京区本郷7-3-1
東京大学 工学部5号館7階
岡本研究室
東京メトロ南北線・東大前駅より徒歩4分
東京メトロ丸ノ内線/都営大江戸線・本郷三丁目駅から徒歩10分
東京メトロ千代田線・根津駅から徒歩12分
電話番号: 03-5841-8702(代表)/03-5841-6536(研究室)
E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp
小田急線/東京メトロ千代田線・代々木上原駅より徒歩12分
小田急線・東北沢駅から徒歩7分
京王井の頭線・駒場東大前駅西口から徒歩10分
京王井の頭線・池ノ上駅から徒歩10分
電話番号:
03-5841-8702(代表)/03-5841-6536(研究室)
E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp