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Our Targets

We are studying on chemistry and life science of

nucleic acid methylation/demethylation using new chemical probes

intracellular RNA behavior using special chemical probes

chromatins consisting of chemically synthesized DNA and histones

single-cell functions through trapping and release of special cells

chemical protection from protein aggregation

aggregation of functional oligonucleotides in a cell

nucleic acid delivery through chemical functionalization

proto-nucleic acids built under prebiotic environments

How are our bodies created from atoms and molecules? We systematically investigate how the atoms and building blocks of biopolymers (nucleic acids and proteins) participate in biological phenomena, introducing synthetic chemistry-based ideas into biological and genetic studies. Research in our group is concerned with diverse aspects of the design and function of biopolymers on an atomic scale. The focus is on the design, synthesis and physical properties of new, man-made biopolymers with various special functions. Also included is the design of unprecedented organic chemical systems for recognizing, transforming and visualizing a single component or atom in biopolymers of interest. These researches are the fundamental studies reflecting the essence of life science on an atomic scale and the material-developing studies to get useful functional materials for the latest studies on life sciences and medical technologies. The lab employs a multidisciplinary approach involving organic synthesis, photophysical chemistry, state-of-the-art spectroscopy, and biological assays to address new approaches to the interface between synthetic chemistry and life science. Current projects include:

  1. Synthesis of ‘superbiopolymers’ containing functional nucleotides and amino acids for elucidation of gene expression function.
  2. Construction of new chemical platforms for collecting specific cells and analyzing cell-cell interactions at the single cell level.
  3. Drug design, cell introduction, and functional analysis based on new chemical ideas.
  4. Chemical exploration of ‘proto-nucleic acids’ under prebiotic conditions.

Collection of Works

Research Category List

Bioorganic Chemistry Organic Synthesis Nucleic Acid Chemistry Chemical Protein Engineering Cell Immobilization
In-Cell Organic Chemistry Live Cell Imaging Epigenetics Cell interaction Raman Spectroscopy
Origin of Life Photodynamic Therapy Dye design      

Bioorganic Chemistry

Organic Synthesis

Nucleic Acid Chemistry

Chemical Protein Engineering

Cell Immobilization

In-Cell Organic Chemistry

Live Cell Imaging

Epigenetics

Cell interaction

Raman Spectroscopy

Origin of Life

Photodynamic Therapy

Dye design

How to join us

Department of Chemistry and Biotechnology (MS/PhD integrated program)

To enroll in the Graduate School of Engineering as a graduate student, you are required to successfully pass an entrance examination.
See the website of the Department of Chemistry and Biotechnology.

http://www.chembio.t.u-tokyo.ac.jp/e/exam.html

Okamoto laboratory strongly encourages you to take the exam of the MS/PhD integrated program. First of all, please contact Okamoto after checking Okamoto’s papers.

Department of Advanced Interdisciplinary Studies (PhD course, no course for master degree)

The course provides mid-career persons with the opportunity to carry out doctoral studies in the university environment. Before requesting application forms, you are advised to contact the department office and inquire whether you can find an appropriate supervisor. If you want to join the Okamoto laboratory, then you also contact Okamoto by e-mail.
See the website of the Graduate School of Engineering, the University of Tokyo

https://www.rcast.u-tokyo.ac.jp/en/index.html

Application for PostDoc position

  1. Contact Okamoto by e-mail
    Contact Okamoto by an email with your CV. If there are some openings in the lab, you would receive an email for the next process.
  2. Apply to the postdoctoral fellowship programs of the Japan Society for the Promotion of Science (JSPS) Contact Okamoto by an email with your CV before preparing the application form. You can find some information on the JSPS postdoctoral fellowship for foreign researchers in the

http://www.jsps.go.jp/english/e-fellow/index.html

Members

Akimitsu Okamoto
Professor

Kunihiko Morihiro
Associate Professor

Takafumi Furuhata
Assistant Professor

Yuki Umeda
DC

Yijing Lin
DC

Yuyuan Chen
DC

Taiki Uno
DC

Xueyang Li
DC

Xuanyu Liao
DC

Yunsong Xu
DC

Yukio Hirase
DC

Zihao Wang
DC

Sijie Li
DC

Soshu Yasuda
DC●‡

Ryotaro Yamamoto
DC

Manami Baba
M2

Naoki Harada
M2

Jotaro Miyamoto
M2

Bumkyu Choi
M2

Xiping Wang
M2

Tamako Aiba
M1

Shuichiro Koga
M1

Ryota Shinohara
M1

Chiharu Moriyama
M1

Hiroki Oiwa
B4

Aoba Okuta
B4

Tento Sugiura
B4

Kei Fujita
B4

Keisuke Horikoshi
B4

Moeko Yamada
B4

Chie Shishido
Secretary

Eriko Yamada
Technical Staff

Mizue Yuuki
Technical Staff

Department of Chemistry and Biotechnology / Department of Advanced Interdisciplinary Studies / JSPS Research Fellowship for Young Scientists / Spring-GX / MERIT-WINGS / Integrated MS/PhD Program (Department of Chemistry and Biotechnology) / JICA-Friendship Project

Current members & Alumni (in Japanese)

Class Information

講義「分子集合体化学」(CH3323L1)担当:岡本 晃充 教授
講義資料:分子集合体化学(1)配布用; 分子集合体化学(3)配布用

講義「生命化学演習」(FEN-CB3m07S1)担当:長尾 翌手可 講師
講義資料:

バーチャル先端研公開 2020
DNAオリガミ(小)折り方
DNAオリガミ(小)型紙

 

 

Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo

Building 5 of the School of Engineering, 7th Floor
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

4 minutes on foot from Todaimae, Namboku Line
10 minutes on foot from Hongo-sanchome, Marunouchi Line / Oedo Line
12 minutes on foot from Nezu, Chiyoda Line

Phone: +81-3-5841-8702 (Office), +81-3-5841-6536 (Laboratory)
E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp

郵便物宛先

〒113-8656 東京都文京区本郷7-3-1
東京大学 大学院工学系研究科 化学生命工学専攻
岡本研究室

宅急便宛先

〒113-8656 東京都文京区本郷7-3-1
東京大学 工学部5号館7階
岡本研究室

東京メトロ南北線・東大前駅より徒歩4分
東京メトロ丸ノ内線/都営大江戸線・本郷三丁目駅から徒歩10分
東京メトロ千代田線・根津駅から徒歩12分

電話番号: 03-5841-8702(代表)/03-5841-6536(研究室)
E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp

小田急線/東京メトロ千代田線・代々木上原駅より徒歩12分
小田急線・東北沢駅から徒歩7分
京王井の頭線・駒場東大前駅西口から徒歩10分
京王井の頭線・池ノ上駅から徒歩10分

電話番号:
03-5841-8702(代表)/03-5841-6536(研究室)
E-mail: okamoto(at)chembio.t.u-tokyo.ac.jp