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Publications

Original Papers | Reviews & Books | Conference Presentations

Original Papers

  • Liu, S.; Morihiro, K.; Takeuchi, F.; Li, Y.; Okamoto, A.
    Interstrand Crosslinking Oligonucleotides Elucidate the Effect of Metal Ions on the Methylation Status of Repetitive DNA Elements
    Front. Chem. 2023, 11, 1122474.
  • Morihiro, K.; Osumi, H.; Morita, S.; Hattori, T.; Baba, M.; Harada, N.; Ohashi, R.; Okamoto, A.
    Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly
    J. Am. Chem. Soc. 2023, 145, 135-142.
  • Akizuki, Y.; Morita, M.; Mori, Y.; Kaiho-Soma, A.; Dixit, S.; Endo, A.; Shimogawa, M.; Hayashi, G.; Naito, N.; Okamoto, A.; Tanaka, K.; Saeki, Y.; Ohtake, F.
    cIAP1-Based Degraders Induce Degradation via Branched Ubiquitin Architectures
    Nat. Chem. Biol. in press.
  • Yamaguchi, S.; Yamamoto, K.; Yamamoto, R.; Takamori, S.; Ishiwatari, A.; Minamihata, K.;  Nagamune, T.; Okamoto, A.
    Intracellular Protein Photoactivation Using Sterically Bulky Caging
    ChemBioChem 2022, 23, e202200476.
  • Kosaka, T.; Yamaguchi, S.; Izuta, S.; Yamahira, S.; Shibasaki, Y.; Tateno, H.; Okamoto, A.
    Bioorthogonal Photoreactive Surfaces for Single-Cell Analysis of Intercellular Communications
    J. Am. Chem. Soc. 2022, 144, 17980-17988.
  • Yamaguchi, S.; Ikeda, R.; Umeda, Y.; Kosaka, T.; Yamahira, S.; Okamoto, A.
    Chemoenzymatic Labeling to Visualize Intercellular Contacts Using Lipidated Sortase A
    ChemBioChem 2022, 23, e202200474.
  • Nakatsu, K.; Okamoto, A.; Hayashi, G.; Murakami, H.
    Repetitive Thiazolidine Deprotection Using a Thioester-Compatible Aldehyde Scavenger for One-Pot Multiple Peptide Ligation
    Angew. Chem. Int. Ed. 2022, 134, e202206240.
  • Yamahira, S.; Misawa, R.; Kosaka, T.; Tan, M.; Izuta, S.; Yamashita, H.; Heike, Y.; Okamoto, A.; Nagamune, T.; Yamaguchi, S.
    Photoactivatable Materials for Versatile Single-Cell Patterning Based on the Photocaging of Cell-Anchoring Moieties through Lipid Self-Assembly
    J. Am. Chem. Soc. 2022, 144, 13154-13162.
  • Pan, M.; Zorbas, C.; Sugaya, M.; Ishiguro, K.; Kato, M.; Nishida, M.; Zhang, H.-F.; Candeias, M. M.; Okamoto, A.; Ishikawa, T.; Soga, T.; Aburatani, H.; Sakai, J.; Matsumura, Y.; Suzuki, T.; Proud, C. G.; Lafontaine, D. L. J.; Osawa, T.
    Glutamine Deficiency in Solid Tumor Cells Confers Resistance to Ribosomal RNA Synthesis Inhibitors
    Nat. Commun. 2022, 13, 3706.
  • Okamoto, A.
    DNA/RNA Fluorescence Imaging by Synthetic Nucleic Acids
    Adv. Exp. Med. Biol. 2021, 1310, 475-493.
  • Itaya, R.; Idei, W.; Nakamura, T.; Nishihara, T.; Kurihara, R.; Okamoto, A.; Tanabe, K.
    Changes of C≡C Triple Bond Vibration that Disclosed Non-Canonical Cytosine Protonation in i-Motif-Forming Oligodeoxynucleotides
    ACS Omega 2021, 6, 31595-31604.
  • Morihiro, K.; Moriyama, Y.; Nemoto, Y.; Osumi, H.; Okamoto, A.
    anti-syn Unnatural Base Pair Enables Alphabet-Expanded DNA Self-Assembly
    J. Am. Chem. Soc. 2021, 143, 14207-14217.
  • Yamaguchi, S.; Takamori, S.; Yamamoto, K.; Ishiwatari, A.; Minamihata, K.; Yamada, E.; Okamoto, A.; Nagamune, T.
    Sterically Bulky Caging of Transferrin for Photoactivatable Intracellular Delivery
    Bioconjugate Chem. 2021, 32, 1535-1540.
  • Koyama, K.; Hayashi, G.; Ueda, H.; Ota, S.; Nagae, G.; Aburatani, H.; Okamoto, A.
    Base-Resolution Analysis of 5-Hydroxymethylcytidine by Selective Oxidation and Reverse Transcription Arrest
    Org. Biomol. Chem. 2021, 19, 6478-6486.
  • Paulson, B.; Shin, Y.; Okamoto, A.; Oh, Y.-M.; Kim, J. K.; Pack, C.-G.
    Poly(A)+ Sensing of Hybridization-Sensitive Fluorescent Oligonucleotide Probe Characterized by Fluorescence Correlation Methods
    Int. J. Mol. Sci. 2021, 22, 6433.
  • Kamo, N.; Hayashi, G.; Okamoto, A.
    Silyl-Protected Propargyl Glycine for Multiple Labeling of Peptides by Chemoselective Silyl-Deprotection
    Tetrahedron Lett. 2021, 73, 153093.
  • Misawa, R.; Minami, T.; Okamoto, A.; Ikeuchi, Y.
    Light-Inducible Control of Cellular Proliferation and Differentiation by a Hedgehog Signaling Inhibitor
    Bioorg. Med. Chem. 2021, 38, 116144.
  • Kamo, N.; Kujirai, T.; Kurumizaka, H.; Murakami, H.; Hayashi, G.; Okamoto, A.
    Organoruthenium-Catalyzed Chemical Protein Synthesis to Elucidate the Functions of Epigenetic Modifications on Heterochromatin Factors
    Chem. Sci. 2021, 12, 5926-5937.
  • Morihiro, K.; Ishinabe, T.; Takatsu, M.; Osumi, H.; Osawa, T.; Okamoto, A.
    Floxuridine Oligomers Activated under Hypoxic Environment
    J. Am. Chem. Soc. 2021, 143, 3340-3347.
  • Hao, F.; Murphy, K. J.; Kujirai, T.; Kamo, N.; Kato, J.; Koyama, M.; Okamato, A.; Hayashi, G.; Kurumizaka, H.; Hayes, J. J.
    Acetylation-Modulated Communication between the H3 N-Terminal Tail Domain and the Intrinsically Disordered H1 C-Terminal Domain
    Nucleic Acids Res. 2020, 48, 11510-11520.
  • Ogata, M.; Hayashi, G.; Ichiu, A.; Okamoto, A.
    L-DNA-Tagged Fluorescence in situ Hybridization for Highly Sensitive Imaging of RNAs in Single Cells
    Org. Biomol. Chem. 2020, 18, 8084-8088.
  • Takemura, S.; Watanabe, H.; Nishihara, T.; Okamoto, A.; Tanabe, K.
    Monitoring Intracellular Metal Ion Complexation with an Acetylene-Tagged Ligand by Raman Spectroscopy
    RSC Adv. 2020, 10, 36119-36123.
  • Yamaguchi, S.; Takagi, R.; Hosogane, T.; Ohashi, Y.; Sakai, Y.; Sakakihara, S.; Iino, R.; Tabata, K.; Noji, H.; Okamoto, A.
    Single Cell Array Enclosed with a Photodegradable Hydrogel in Microwells for Image-Based Cell Classification and Selective Photorelease of Cells
    ACS Appl. Bio Mater. 2020, 3, 5887-5895.
  • Nakatsu, K.; Yanase, M.; Hayashi, G.; Okamoto, A.
    Fmoc-Compatible and C-terminal-Sequence-Independent Peptide Alkyl Thioester Formation Using Cysteinylprolyl Imide
    Org. Lett. 2020, 22, 4670-4674.
  • Misawa, R.; Minami, T.; Okamoto, A.; Ikeuchi, Y.
    A Light-Inducible Hedgehog Signaling Activator Modulates Proliferation and Differentiation of Neural Cells
    ACS Chem. Biol. 2020, 15, 1595-1603.
  • Chen, J.; Morihiro, K.; Fukui, D.; Guo, L.; Okamoto, A.
    Live Cell Sensing of Telomerase Activity Using Hybridization-Sensitive Fluorescent Oligonucleotide Probes
    ChemBioChem 2020, 21, 1022-1027.
  • Morihiro, K.; Okamoto, A.
    A Highly Constrained Nucleic Acid Analogue Based on α-L-Threosamine
    Nucleosides Nucleotides Nucleic Acids 2020, 39, 270-279.
  • Jarzebska, N. A.; Yamaguchi, S.; Izuta, S.; Kosaka, T.; Yamahira, S.; Nagamune, T.; Okamoto, A.
    Photo-responsive materials with strong cell trapping ability for light-guided manipulation of nonadherent cells
    Biomater. Sci. 2019, 7, 4514-4518.
  • Kamo, N.; Hayashi, G.; Okamoto, A.
    Chemical Synthesis of Cys-Containing Protein via Chemoselective Deprotection with Different Palladium Complexes
    Org. Lett. 2019, 21, 8378-8382.
  • Yanase, M.; Nakatsu, K.; Cardos, C. J.; Konda, Y.; Hayashi, G.; Okamoto, A.
    Cysteinylprolyl Imide (CPI) Peptide: A Highly Reactive and Easily Accessible Crypto-thioester for Chemical Protein Synthesis
    Chem. Sci. 2019, 10, 5967-5975.
  • Yamaguchi, S.; Higashi, K.; Azuma, T.; Okamoto, A.
    Supramolecular Polymeric Hydrogels for Ultrasound-guided Protein Release
    Biotechnol. J. 2019, 14, 1800530.
  • Hayashi, G.; Yanase, M.; Nakatsuka, Y.; Okamoto, A.
    Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold
    Biomacromolecules 2019, 20, 1246-1253.
  • Izuta, S.; Yamaguchi, S.; Kosaka, T.; Okamoto, A.
    Reversible and Photoresponsive Immobilization of Nonadherent Cells by Spiropyran-Conjugated PEG-Lipids
    ACS Appl. Bio Mater. 2019, 2, 33-38.
  • Usami, K.; Xiao, K.; Okamoto, A.
    Efficient Ketose Production by Hydroxyapatite Catalyst in a Continuous Flow Module
    ACS Sustainable Chem. Eng. 2019, 7, 3372-3377.
  • Shiraogawa, T.; Candel, G.; Fukuda, R.; Ciofini, I.; Adamo, C.; Okamoto, A.; Ehara M.
    Photophysical Properties of Fluorescent Imaging Biological Probes of Nucleic Acids: SAC-CI and TD-DFT Study
    J. Comput. Chem. 2019, 40, 127-134.
  • Kamo, N.; Hayashi, G.; Okamoto, A.
    Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation
    Angew. Chem. Int. Ed. 2018, 57, 16533-16537.
    Highlighted in Synfacts (2019; 15(02): 0204. DOI: 10.1055/s-0037-1611963) and Faculty Opinions (27 Dec 2018; DOI: 10.3410/f.734273258.793554521)
  • Sueoka, T.; Koyama, K.; Hayashi, G.; Okamoto, A.
    Chemistry-driven Epigenetic Investigation of Histone and DNA Modifications
    Chem. Rec. 2018, 18, 1727-1744.
  • Debnath, T. K.; Okamoto, A.
    Osmium Tag for Posttranscriptionally Modified RNA
    ChemBioChem 2018, 19, 1653-1656.
  • Kamo, N.; Hayashi, G.; Okamoto, A.
    Efficient peptide ligation between allyl-protected Asp and Cys followed by palladium-mediated deprotection
    Chem. Commun. 2018, 54, 4337-4340.
  • Izuta, S.; Yamaguchi, S.; Misawa, R.; Yamahira, S.; Tan, M.; Kawahara, M.; Suzuki, T.; Takagi, T.; Sato, K.; Nakamura, M.; Nagamune, T.; Okamoto, A.
    Microfluidic Preparation of Anchored Cell Membrane Sheets for in Vitro Analyses and Manipulation of the Cytoplasmic Face
    Sci. Rep. 2017, 7, 14962.
  • Hayashi, G.; Tamai, M.; Okamoto, A.
    Hybridization-Sensitive Fluorescent Oligonucleotide Probe Conjugated with Cell-Penetrating Peptides for Enhanced Cellular Uptake
    Chem. Lett. 2017, 46, 1803-1806.
  • Usami, K.; Okamoto, A.
    Hydroxyapatite: catalyst for a one-pot pentose formation
    Org. Biomol. Chem. 2017, 15, 8888-8893.
  • Sueoka, T.; Hayashi, G.; Okamoto, A.
    Regulation of the Stability of the Histone H2A-H2B Dimer by H2A Tyr57 Phosphorylation
    Biochemistry 2017, 56, 4767-4772.
  • Guo, L.; Okamoto, A.
    Fluorescence-switching RNA for detection of bacterial ribosome
    Chem. Commun. 2017, 53, 9406-9409.
  • Hayashi, G.; Kamo, N.; Okamoto, A.
    Chemical synthesis of dual labeled protein via differently protected alkynes enables intramolecular FRET analysis
    Chem. Commun. 2017, 53, 5918-5921.
  • Matsushita, T.; Moriyama, Y.; Nagae, G.; Aburatani, H.; Okamoto, A.
    DNA-friendly Cu(II)/TEMPO-catalyzed 5-hydroxymethylcytosine-specific oxidation
    Chem. Commun. 2017, 53, 5756-5759.
  • Yamaguchi, S.; Matsushita, T.; Izuta, S.; Katada, S.; Ura, M.; Ikeda, T. ;Hayashi, G.; Suzuki, Y.; Kobayashi, Y.; Tokunaga, K.; Ozeki, Y.; Okamoto, A.
    Chemically-activatable alkyne-tagged probe for imaging microdomains in lipid bilayer membranes
    Sci. Rep. 2017, 7, 41007.
  • Hayashi, G.; Koyama, K.; Shiota, H.; Kamio, A.; Umeda, T.; Nagae, G.; Aburatani, H.; Okamoto, A.
    Base-Resolution Analysis of 5-Hydroxymethylcytosine by One-Pot Bisulfite-Free Chemical Conversion with Peroxotungstate
    J. Am. Chem. Soc. 2016, 138 (43), 14178-14181.
  • Yamaguchi,S.; Ura, M.; Izuta, S.; Okamoto, A.
    Chemically Activatable Alkyne Tag for Low pH-Enhanced Molecular Labeling on Living Cells
    Bioconjugate Chem. 2016, 27 (9), 1976-1980.
  • Kitagawa, M.; Okamoto, A.
    Rapid nuclear import of short nucleic acids
    Bioorg. Med. Chem. Lett. 2016, 26 (19), 4568-4570.
  • Hayashi, G.; Sueoka, T.; Okamoto, A.
    In vitro and in cell analysis of chemically synthesized histone H2A with multiple modifications
    Chem. Commun. 2016, 52, 4999-5002.
  • Oomoto, I.; Suzuki-Hirano, A.; Umeshima, H.; Han, Y.-W.; Yanagisawa, H.; Carlton, P.; Harada, Y.; Kengaku, M.; Okamoto, A.; Shimogori, T.; Wang, D. O.
    ECHO-liveFISH: in vivo RNA Labeling Reveals Dynamic Regulation of Nuclear RNA Foci in Living Tissues
    Nucleic Acid Res. 2015, 43 (19), e126.
  • Jeong, H. S.; Hayashi, G.; Okamoto, A.
    Diazirine Photocrosslinking Recruits Activated FTO Demethylase Complexes for Specific N6-methyladenosine Recognition
    ACS Chem. Biol. 2015, 10 (6), 1450-1455.
  • Wang, D. O.; Okamoto, A.
    ECHO-FISH for Gene Transcript Detection in Neuronal and Other Cells and Subcellular Compartments
    Neuromethods 2015, 99, 559-584
  • Yamamoto, K.; Chikaoka, Y.; Hayashi, G.; Sakamoto, R.; Yamamoto, R.; Sugiyama, A.; Kodama, T.; Okamoto, A.; Kawamura, T.
    Middle-down and chemical proteomic approaches to reveal histone H4 modification dynamics in cell cycle ― Label-free semi-quantification of histone tail peptide modifications including phosphorylation 3 and highly sensitive capture of histone PTM binding proteins using photo-reactive crosslinkers
    Mass Spectrom. 2015, 4 (1), A0039.
  • Hayashi, G.; Yanase, M.; Takeda, K.; Sakakibara, D.; Sakamoto, R.; Wang, D. O.; Okamoto, A.
    Hybridization-sensitive fluorescent oligonucleotide probe conjugated with a bulky module for compartment-specific mRNA monitoring in a living cell
    Bioconjugate Chem. 2015, 26 (3), 412-417.
  • Hayashi, G.; Sakamoto, R.; Okamoto, A.
    2-Oxazoline Formation for Selective Chemical Labeling of 5-Hydroxylysine
    Chem. Asian J. 2015, 10 (5), 1138-1141.
  • Wang, D. O.; Okamoto, A.
    Visualization of Nucleic Acids with Synthetic Excitation-Controlled Fluorescent Oligonucleotide Probes
    Methods Mol. Biol. 2015, 1262, 69-87.
  • Okamoto, A.
    Modified ECHO probes for highly specific RNA detection in living cells.
    Trends Org. Chem. 2014, 17, 45-57
  • Yang, Y. G.; Zhao, X.; Yang, Y.; Sun, B. F.; Shi, Y.; Yang, X.; Xiao, W.; Hao, Y.; Ping, X.-L.; Chen, Y.; Wang, W.-J.; Jin, K.-X.; Wang, X.; Huang, C.; Fu, Y.; Ge, X.; Song, S.; Jeong, H. S.; Yanagisawa, H.; Niu, Y.; Jia, G.; Wu, W.; Tong, W.-M.; Okamoto, A.; He, C.; Danielsen, J. M.; Wang, X.
    FTO-Dependent Demethylation of N6-Methyladenosine Regulates mRNA Splicing and Is Required for Adipogenesis
    Cell Res. 2014, 24, 1403-1419.
  • Okamoto, A.
    DNA-Osmium Complexes: Recent Developments for Operative Chemical Analysis of DNA Epigenetic Modification
    ChemMedChem 2014, 9 (9), 1958-1965.
  • Shiura, H.; Okamoto, A.; Sasaki, H.; Abe, K.
    Whole-mount MeFISH: A novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression
    PLoS ONE 2014, 9 (4), e95750.
  • Okamoto, A.
    Application of caged fluorescent nucleotides to live-cell RNA imaging
    Methods Mol. Biol. 2013, 1039, 303-318.
  • Li, Y.; Miyanari, Y.; Shirane, K.; Nitta, H.; Kubota, T.; Ohashi, H.; Okamoto, A.; Sasaki, H.
    Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes
    Nucleic Acids Res. 2013, 41 (19), e186.
  • Hayashi, G.; Okamoto, A.
    Probe Design for Effective Fluorescent Imaging of Intracellular RNA
    Chem. Rec. 2013, 13 (2), 209-217.
  • Shin, H.-S.; Okamoto, A.; Sako, Y.; Kim, S. W.; Kim, S. Y.; Pack, C.-G.
    Characterization of Triplet State of Hybridization-Sensitive DNA Probe by Using Fluorescence Correlation Spectroscopy
    J. Phys. Chem. A 2013, 117 (1), 27-33.
  • Ikeda, S.; Yanagisawa, H.; Yuki, M.; Okamoto, A.
    Fluorescent triplex-forming DNA oligonucleotides labeled with a thiazole orange dimer unit
    Artif. DNA PNA XNA 2013, 4 (1), 19-27.
  • Okamoto, A.; Sugizaki, K.; Yuki, M.; Yanagisawa, H.; Ikeda, S.; Sueoka, T.; Hayashi, G.; Wang, D. O.
    A nucleic acid probe labeled with desmethyl thiazole orange: A new type of hybridization-sensitive fluorescent oligonucleotide for live-cell RNA imaging
    Org. Biomol. Chem. 2013, 11 (2), 362-371.
  • Sugizaki, K.; Nakamura, A.; Yanagisawa, H.; Okamoto, A.
    Ligand incorporation site in 5-methylcytosine detection probe modulating the site of osmium complexation with the target DNA
    Chem. Biodiv. 2012, 9 (9), 2000-2007.
  • Shin, H.-S.; Okamoto, A.; Sako, Y.; Kim, S. W.; Pack, C.-G.; Kim, S.
    Radiationless Deactivation of Hybridization-Sensitive DNA Probe
    J. Luminescence 2012, 132, 2566-2571.
  • Wang, D. O.; Okamoto, A.
    ECHO probes: fluorescence emission control for nucleic acid imaging
    J. Photochem. Photobiol. C-Photochem. Rev. 2012, 13, 112-123.
  • Wang, D. O.; Matsuno, H.; Ikeda, S.; Nakamura, A.; Yanagisawa, H.; Hayashi, Y.; Okamoto, A.
    A Quick and Simple FISH Protocol with Hybridization-sensitive Fluorescent Linear Oligodeoxynucleotide Probes
    RNA 2012, 18 (1), 166-175.
  • Ikeda, S.; Kubota, T.; Wang, D. O.; Yanagisawa, H.; Umemoto, T.; Okamoto, A.
    Design and Synthesis of Caged Fluorescent Nucleotides and Application to Live Cell RNA Imaging
    ChemBioChem 2011, 12 (18), 2871-2880.
  • Okamoto, A.; Sugizaki, K.; Nakamura, A.; Yanagisawa, H.; Ikeda, S.
    5-Hydroxymethylcytosine-selective oxidation with peroxotungstate
    Chem. Commun. 2011, 47 (40), 11231-11233.
  • Tainaka, K.; Okamoto, A.
    ICON probe: Synthesis and DNA methylation typing
    Curr. Protoc. Nucleic Acid Chem. 2011, 8.7.1-8.7.17.
  • Okamoto, A.; Ikeda, S.; Kubota, T.; Wang, D. O.
    Design of binary energy transfer on nucleic acids
    Photomed. Photobiol. 2011, 33, 45-46.
  • Kubota, T.; Ikeda, S.; Yanagisawa, H.; Yuki, M.; Okamoto, A.
    Cy5-conjugated Hybridization-sensitive Fluorescent Oligonucleotides for Ratiometric Analysis of Nuclear Poly(A)+ RNA
    Bioconjugate Chem. 2011, 22 (8), 1625-1630.
  • Ikeda, S.; Kubota, T.; Wang, D. O.; Yanagisawa, H.; Yuki, M.; Okamoto, A.
    Emission Control by Binary Energy Transfer Processes on Oligouridine
    Org. Biomol. Chem. 2011, 9 (19), 6598-6603.
  • Nomura, A.; Sugizaki, K.; Yanagisawa, H.; Okamoto, A.
    Discrimination between 5-hydroxymethylcytosine and 5-methylcytosine by a chemically designed peptide
    Chem. Commun. 2011, 47 (29), 8277-8279.
  • Okamoto, A.
    ECHO Probes: A Concept of Fluorescence Control for Practical Nucleic Acid Sensing
    Chem. Soc. Rev. 2011, 40 (12), 5815-5828.
  • Sugizaki, K.; Umemoto, T.; Okamoto, A.
    On-chip DNA methylation analysis using osmium complexation
    J. Nucleic Acids 2011, 2011, 480570.
  • Ikeda, S.; Yanagisawa, H.; Nakamura, A.; Wang, D. O.; Yuki, M.; Okamoto, A.
    Hybridization-sensitive fluorescence control in the near-infrared wavelength range
    Org. Biomol. Chem. 2011, 9 (11), 4199-4204.
  • Sugizaki, K.; Ikeda, S.; Yanagisawa, H.; Okamoto, A.
    Facile synthesis of hydroxymethylcytosine-containing oligonucleotides and their reactivity upon osmium oxidation
    Org. Biomol. Chem. 2011, 9 (11), 4176-4181.
  • Nomura, A.; Okamoto, A.
    Phosphopeptides Designed for 5-Methylcytosine Recognition
    Biochemistry 2011, 50 (16), 3376-3385.
  • Nomura, A.; Okamoto, A.
    Recognition of methylcytosine in duplex DNA by artificial zinc finger peptide
    Peptide Sci. 2011, 2010, 226.
  • Okamoto, A.; Ikeda, S.; Kubota, T.
    Fluorescent nucleotide for RNA detection
    Photomed. Photobiol. 2010, 32, 37-38.
  • Sugizaki, K.; Okamoto, A.
    ECHO-LNA conjugates: Hybridization-sensitive fluorescence and its application to fluorescent detection of various RNA strands
    Bioconjugate Chem. 2010, 21 (12), 2276-2281.
  • Kubota, T.; Ikeda, S.; Yanagisawa, H.; Yuki, M.; Okamoto, A.
    Sets of RNA repeated tags and hybridization-sensitive fluorescent probes for distinct images of RNA in a living cell
    PLoS ONE 2010, 5 (9), e13003.
  • Nomura, A.; Okamoto, A.
    Design of a novel methylcytosine-recognition zinc finger peptide
    Peptide. Sci. 2010, 2009, 345-346.
  • Okamoto, A.
    Excitonic interaction: Another photophysical process for fluorescence-controlled nucleic acid sensing
    Chem. Rec. 2010, 10 (3), 188-196.
  • Yoshida, Y.; Niwa, K.; Yamada, K.; Tokeshi, M.; Baba, Y.; Saito, Y.; Okamoto, A.; Saito, I.
    A Probe Containing Two Base-discriminating Fluorescent (BDF) Nucleosides for SNP Typing
    Chem. Lett. 2010, 39 (2), 116-117.
  • Lezhava, A.; Ishidao, T.; Ishizu, Y.; Naito, K.; Hanami, T.; Katayama, A.; Kogo, Y.; Soma, T.; Ikeda, S.; Murakami, K.; Nogawa, C.; Itoh, M.; Mitani, Y.; Harbers, M.; Okamoto, A.; Hayashizaki, Y.
    Exciton-Primer Mediated SNP Detection in SmartAmp2 Reactions
    Hum. Mutat. 2010, 31 (2), 208-217.
  • Ikeda, S.; Kubota, T.; Yuki, M.; Yanagisawa, H.; Tsuruma, S.; Okamoto, A.
    Hybridization-sensitive fluorescent DNA probe with self-avoidance ability
    Org. Biomol. Chem. 2010, 8 (3), 546-551. (with the journal cover)
  • Ikeda, S.; Yuki, M.; Yanagisawa, H.; Okamoto, A.
    Doubly thiazole orange-labeled cytidine for functional expansion of a hybridization-sensitive probe
    Tetrahedron Lett. 2009, 50 (51), 7191-7195.
  • Ikeda, S.; Kubota, T.; Yuki, M.; Okamoto, A.
    Exciton-Controlled Hybridization-Sensitive Fluorescent Probes: Multicolor Detection of Nucleic Acids
    Angew. Chem. 2009, 121 (35), 6602-6606; Angew. Chem., Int. Ed. 2009, 48 (35), 6480-6484.
  • # Nomura, A.; Tainaka, K.; Okamoto, A.
    Osmium complex binding to mismatched methylcytosine: effect of adjacent bases
    Nucleic Acids Symp. Ser. 2009, 53, 207-208.
  • # Ikeda, S.; Kubota, T.; Yanagisawa, H.; Yuki, M.; Okamoto, A.
    Synthesis of exciton-controlled fluorescent probes for RNA imaging
    Nucleic Acids Symp. Ser. 2009, 53, 155-156.
  • # Okamoto, A.; Ikeda, S.; Kubota, T.; Yuki, M.; Yanagisawa, H.
    Exciton-controlled fluorescence: Application to hybridization-sensitive fluorescent DNA probe
    Nucleic Acids Symp. Ser. 2009, 53, 49-50.
  • Kubota, T.; Ikeda, S.; Yanagisawa, H.; Yuki, M.; Okamoto, A.
    Hybridization-Sensitive Fluorescent Probe for Long-Term Monitoring of Intracellular RNA
    Bioconjugate Chem. 2009, 20 (6), 1256-1261.
  • Okamoto, A.
    Synthesis and Use of Osmium-DNA Complexes
    J. Synth. Org. Chem. Jpn. 2009, 67 (7), 680-686.
  • Nomura, A.; Okamoto, A.
    Photoresponsive Tandem Zinc Finger Peptide
    Chem. Commun. 2009, 1906-1908.
  • Nomura, A.; Tainaka, K.; Okamoto, A.
    Osmium Complexation of Mismatched DNA: Effect of the Bases Adjacent to Mismatched 5-Methylcytosine
    Bioconjugate Chem. 2009, 20 (3), 603-607.
  • Nomura, A.; Okamoto, A.
    Photo-Control of DNA Binding of a Zinc Finger Peptide Containing Azobenzene
    Peptide. Sci. 2009, 2008, 405-406.
  • Kubota, T.; Ikeda, S.; Okamoto, A.
    Doubly Thiazole Orange-Labeled DNA for Live Cell RNA Imaging
    Bull. Chem. Soc. Jpn. 2009, 82 (1), 110-117.
  • Okamoto, A.
    Chemical approach toward efficient DNA methylation analysis
    Org. Biomol. Chem. 2009, 7 (1), 21-26. (with the journal cover)
  • Nomura, A.; Okamoto, A.
    Heterogeneity of osmium oxidation efficiency at consecutive thymines
    Org. Biomol. Chem. 2008, 6 (21), 3905-3907.
  • # Nomura, A.; Okamoto, A.
    Reactivity of Thymine Doublet in Single Strand DNA with Osmium Reagent
    Nucleic Acids Symp. Ser. 2008, 52, 433-434.
  • # Kubota, T.; Ikeda, S.; Okamoto, A.
    Intracellular mRNA imaging with a hybridization sensitive fluorescent nucleotide
    Nucleic Acids Symp. Ser. 2008, 52, 355-356.
  • # Okamoto, A.; Kubota, T.; Ikeda, S.
    Design of a fluorescent probe for DNA/RNA imaging
    Nucleic Acids Symp. Ser. 2008, 52, 231-232.
  • Ikeda, S.; Kubota, T.; Kino, K.; Okamoto, A.
    Sequence Dependence of Fluorescence Emission and Quenching of Doubly Thiazole Orange-Labeled DNA: Effective Design of a Hybridization-Sensitive Probe
    Bioconjugate Chem. 2008, 19 (8), 1719-1725.
  • Tainaka, K.; Okamoto, A.
    Synthesis of Bipyridine-Adenine Conjugates for Methylation Analysis
    Coll. Symp. Ser. 2008, 10, 146-149.
  • Ikeda, S.; Okamoto, A.
    Hybridization-Sensitive On-Off DNA Probe: Application of the Exciton Coupling Effect to Effective Fluorescence Quenching
    Chem. Asian J. 2008, 3 (6), 958-968. (with the journal cover)
  • Nomura, A.; Okamoto, A.
    Chemical Modification of Zinc Finger Peptide with Photo-Switching Unit
    Peptide. Sci. 2008, 2007, 393-394.
  • Umemoto, T.; Okamoto, A.
    Synthesis and characterization of the 5-methyl-2′-deoxycytidine glycol-dioxoosmium-bipyridine ternary complex in DNA
    Org. Biomol. Chem. 2008, 6 (2), 269-271.
  • Tanaka, K.; Okamoto, A.
    Design of a pyrene-containing fluorescence probe for labeling of RNA poly(A) tracts
    Bioorg. Med. Chem. 2008, 16 (1), 400-404.
  • Tanaka, K.; Tainaka, K.; Umemoto, T.; Nomura, A.; Okamoto, A.
    An osmium-DNA interstrand complex: Application to facile DNA methylation analysis
    J. Am. Chem. Soc. 2007, 129 (46), 14511-14517.
  • Okamoto, A.
    5-Methylcytosine-Selective Osmium Oxidation
    Nucleosides Nucleotides Nucleic Acids 2007, 26 (10-12), 1601-1604.
  • Ikeda, S.; Okamoto, A.
    pH-dependent fluorescence of uncharged benzothiazole-based dyes binding to DNA
    Photochem. Photobiol. Sci. 2007, 6 (11), 1197-1201.
  • Tainaka, K.; Saito, I.; Okamoto, A.
    Design of fluorescent DNA monitoring its dielectric microenvironment
    Photomed. Photobiol. 2007, 29, 12-13.
  • # Okamoto, A.; Tanaka, K.; Tainaka, K.; Umemoto, T.; Nomura, A.
    DNA methylation analysis using metal complex formation
    Nucleic Acids Symp. Ser. 2007, 51, 27-28.
  • # Umemoto, T.; Tainaka, K.; Tanaka, K.; Okamoto, A.
    Chemistry of osmium-DNA complexes
    Nucleic Acids Symp. Ser. 2007, 51, 175-176.
  • # Kubota, T.; Ikeda, S.; Okamoto, A.
    RNA analysis with a novel fluorescent oligonucleotide
    Nucleic Acids Symp. Ser. 2007, 51, 291-292.
  • # Nomura, A.; Tainaka, K.; Okamoto, A.
    Selective oxidation of methylcytosine in single base pair mismatches by osmium complex
    Nucleic Acids Symp. Ser. 2007, 51, 299-300.
  • # Ikeda, S.; Okamoto, A.
    Photochemical properties of novel fluorescent probes for detection of DNA
    Nucleic Acids Symp. Ser. 2007, 51, 301-302.
  • Hoskins, A. A.; Morar, M.; Kappock, T. J.; Mathews, I. I.; Zaugg, J. B.; Barder, T. E.; Peng, P.; Okamoto, A.; Ealick, S. E.; Stubbe, J.
    N5-CAIR Mutase: Role of a CO2 Binding Site and Substrate Movement in Catalysis
    Biochemistry 2007, 46 (10), 2842-2855.
  • Tanaka, K.; Tainaka, K.; Kamei, T.; Okamoto, A.
    Direct Labeling of 5-Methylcytosine and Its Applications
    J. Am. Chem. Soc. 2007, 129 (17), 5612-5620.
  • Tanaka, K.; Kamei, T.; Okamoto, A.
    Production of radical species and modification of DNA through one-electron reduction with indium metal
    Tetrahedron Lett. 2007, 48 (18), 3167-3169.
  • Tainaka, K.; Tanaka, K.; Ikeda, S.; Nishiza, K.-i.; Unzai, T.; Fujiwara, Y.; Saito, I.; Okamoto, A.
    PRODAN-conjugated DNA: Synthesis and Photochemical Properties
    J. Am. Chem. Soc. 2007, 129 (15), 4776-4784.
  • Tanaka, K.; Okamoto, A.
    Degradation of DNA by bisulfite treatment
    Bioorg. Med. Chem. Lett. 2007, 17 (7), 1912-1915.
  • Tanaka, K.; Okamoto, A.; Saito, I.
    Artificial Nucleobases for Hole Transport
    J. Synth. Org. Chem. Jpn. 2007, 65 (3), 204-215.
  • Okamoto, A.; Tainaka, K.; Unzai, T.; Saito, I.
    Synthesis and fluorescence properties of dimethylaminonaphthalene-deoxyuridine conjugates as micropolarity-sensitive probes
    Tetrahedron 2007, 63 (17), 3465-3470.
  • Tanaka, K.; Tainaka, K.; Okamoto, A.
    Methylation-Selective Fluorescence Quenching by Osmium Complexation
    Bioorg. Med. Chem. 2007, 15 (4), 1615-1621.
  • Okamoto, A.; Tainaka, K.; Saito, I.
    Effect of Single Nucleotide Alteration in Hybridized RNA on Fluorescence Intensity of Dimethylaminonaphthalene-Labeled DNA
    Photomed. Photobiol. 2006, 28, 31-32.
  • # Kodate, S.; Wada, H.; Suzuka, I.; Okamoto, A.; Tainaka, K.; Saito, Y.; Saito, I.
    Luminescence properties of dual fluorescent pyrene derivatives used as DNA probe molecule
    Nucleic Acids Symp. Ser. 2006, 50, 211-212.
  • # Tanaka, K.; Tainaka, K.; Kamei, T.; Okamoto, A.
    Development of electrochemical detection for methylcytosine and its application
    Nucleic Acids Symp. Ser. 2006, 50, 141-142.
  • # Tanaka, K.; Tainaka, K.; Okamoto, A.
    Fluorescence quenching by methylcytosine- metal complexation
    Nucleic Acids Symp. Ser. 2006, 50, 139-140.
  • # Tanaka, K.; Tainaka, K.; Fujishima, S.; Okamoto, A.
    Photochemical evaluation of dual fluorescence of a novel DNA groove binder
    Nucleic Acids Symp. Ser. 2006, 50, 137-138.
  • # Tanaka, K.; Tainaka, K.; Kamei, T.; Okamoto, A.
    Development of fluorescence-labeling method for methylcytosine with metal complexation
    Nucleic Acids Symp. Ser. 2006, 50, 135-136.
  • # Tainaka, K.; Ikeda, S.; Tanaka, K.; Nishiza, K.-i.; Fujiwara, Y.; Okamoto, A.; Saito, I.
    Development of novel PRODAN-labeled nucleosides as base-discriminating fluorescent probes
    Nucleic Acids Symp. Ser. 2006, 50, 133-134.
  • # Tainaka, K.; Ikeda, S.; Tanaka, K.; Nishiza, K.-i.; Unzai, T.; Okamoto, A.; Saito, I.
    Synthesis and properties of novel PRODAN-labeled uridine
    Nucleic Acids Symp. Ser. 2006, 50, 131-132.
  • # Tainaka, K.; Tanaka, K.; Okamoto, A.
    Development of bipyridine-modified nucleobase for methylcytosine-selective crosslink reaction
    Nucleic Acids Symp. Ser. 2006, 50, 129-130.
  • # Tanaka, K.; Kamei, T.; Okamoto, A.
    Evaluation of novel one-electron reduction with metal in DNA
    Nucleic Acids Symp. Ser. 2006, 50, 127-128.
  • Okamoto, A.; Tainaka, K.; Kamei, T.
    Sequence-selective osmium oxidation of DNA: Efficient distinction between 5-methylcytosine and cytosine
    Org. Biomol. Chem. 2006, 4 (9), 1638-1640. (with the journal cover)
  • Saito, I.; Saito, Y.; Hanawa, K.; Hayashi, K.; Motegi, K.; Bag, S. S.; Dohno, C.; Ichiba, T.; Tainaka, K.; Okamoto, A.
    Highly selective fluorescent nucleobases for designing base-discriminating fluorescent probes
    Pure Appl. Chem. 2006, 78 (12), 2305-2312.
  • Okamoto, A.; Tainaka, K.; Fujiwara, Y.
    Nile Red nucleoside: Design of a solvatofluorochromic nucleoside as an indicator of micropolarity around DNA
    J. Org. Chem. 2006, 71 (9), 3592-3598.
  • Tanabe, K.; Iida, H.; Haruna, K.-i.; Kamei, T.; Okamoto, A.; Nishimoto, S.-i.
    Electrochemical Evaluation of Alternating Duplex-Triplex Conversion Effect on the Anthraquinone-Photoinduced Hole Transport through DNA Duplex Immobilized on a Gold Electrode
    J. Am. Chem. Soc. 2006, 128 (3), 692-693.
  • Okamoto, A.; Tainaka, K.; Ochi, Y.; Kanatani, K.; Saito, I.
    Simple SNP typing assay using a base-discriminating fluorescent probe
    Mol. BioSyst. 2006, 2 (2), 122-127. (with the journal cover)
  • Okamoto, A.; Kamei, T.; Saito, I.
    DNA hole transport: application to effective photoelectrochemical SNP typing
    J. Am. Chem. Soc. 2006, 128 (2), 658-662.
  • Okamoto, A.; Kamei, T.; Saito, I.
    Photostimulated Hole Transport a Bulged DNA Duplex Immobilized on a Gold Electrode
    Photomed. Photobiol. 2005, 27, 27-28.
  • Okamoto, A.
    Synthesis of Highly Functional Nucleic Acids and Their Application to DNA Technology
    Bull. Chem. Soc. Jpn. 2005, 78 (12), 2083-2097.
  • Dohno, C.; Okamoto, A.; Saito, I.
    Stable, Specific, and Reversible Base Pairing via Schiff Base
    J. Am. Chem. Soc. 2005, 127 (47), 16681-16684.
  • Saito, Y.; Hanawa, K.; Motegi, K.; Omoto, K.; Okamoto, A.; Saito, I.
    Synthesis and properties of purine-type base-discriminating fluorescent (BDF) nucleosides: Distinction of thymine by fluorescence-labeled deoxyadenosine
    Tetrahedron Lett. 2005, 46 (44), 7605-7608.
  • Okamoto, A.; Tainaka, K.; Nishiza, K.-i.; Saito, I.
    Monitoring DNA Structures by Dual Fluorescence of Pyrene Derivatives
    J. Am. Chem. Soc. 2005, 127 (38), 13128-13129.
  • Okamoto, A.; Tainaka, K.; Saito, I.
    A Dielectric-Sensitive Fluorescent DNA Probe for Monitoring Polarities on the Interior of a DNA-Binding Protein
    Bioconjugate Chem. 2005, 16 (5), 1105-1111.
  • Okamoto, A.; Saito, Y.; Saito, I.
    Design of base-discriminating fluorescent nucleosides
    J. Photochem. Photobiol. C-Photochem. Rev. 2005, 6 (2-3), 108-122.
  • # Okamoto, A.; Tainaka, K.
    Sequence-selective 5-methylcytosine oxidation for epigenotyping
    Nucleic Acids Symp. Ser. 2005, 49, 45-46.
  • # Okamoto, A.; Tainaka, K.; Ochi, Y.; Saito. I.
    SNPs typing by base-discriminating fluorescence DNA probe
    Nucleic Acids Symp. Ser. 2005, 49, 201-202.
  • # Saito, Y.; Hanawa, K.; Hayashi, K.; Motegi, K.; Okamoto, A.; Saito, I.
    Synthesis and properties of novel base-discriminating fluorescent (BDF) nucleosides
    Nucleic Acids Symp. Ser. 2005, 49, 153-154.
  • # Tainaka, K.; Fujiwara, Y.; Okamoto, A.
    Nile Red nucleoside: Novel nucleoside analog with a fluorophore replacing the DNA base
    Nucleic Acids Symp. Ser. 2005, 49, 155-156.
  • # Okamoto, A.; Kamei, T.; Saito, I.
    Genotyping with hole-transporting DNA self-assembled monolayer
    Nucleic Acids Symp. Ser. 2005, 49, 227-228.
  • # Dohno, C.; Okamoto, A.; Saito, I.
    Schiff base-mediated base pairing
    Nucleic Acids Symp. Ser. 2005, 49, 185-186.
  • Okamoto, A.; Ochi, Y.; Saito, I.
    Modulation of base selectivity for a base-discriminating fluorescent nucleobase by addition of mercury ion
    Bioorg. Med. Chem. Lett. 2005, 15 (19), 4279-4281.
  • Tanaka, K.; Okamoto, A.; Saito, I.
    Public-key system using DNA as a one-way function for key distribution
    Biosystems 2005, 81 (1), 25-29.
  • Okamoto, A.; Ochi, Y.; Saito, I.
    Fluorometric sensing of the salt-induced B-Z DNA transition by combination of two pyrene-labeled nucleobases
    Chem. Commun. 2005, (9), 1128-1130.
  • Okamoto, A.; Inasaki, T.; Saito, I.
    Synthesis and ESR studies of nitronyl nitroxide-tethered oligodeoxynucleotides
    Tetrahedron Lett. 2005, 46 (5), 791-795.
  • Okamoto, A.; Kanatani, K.; Saito, Y.; Saito, I.
    Fluorescence properties of DNA probes multiply labeled by a base-discriminating fluorescent nucleobase, PyU
    Photomed. Photobiol. 2004, 26, 77-78.
  • Okamoto, A.; Kamei, T.; Tanaka, K.; Saito, I.
    Photostimulated Hole Transport through a DNA Duplex Immobilized on a Gold Electrode
    J. Am. Chem. Soc. 2004, 126 (45), 14732-14733.
  • Saito, Y.; Miyauchi, Y.; Okamoto, A.; Saito, I.
    Synthesis and properties of novel base-discriminating fluorescent (BDF) nucleosides: A highly polarity-sensitive fluorophore for SNP typing
    Tetrahedron Lett. 2004, 45 (42), 7827-7831.
  • Okamoto, A.; Tanaka, K.; Nishiza, K.-i.; Saito, I.
    Synthesis of an Artificial Hole-Transporting Nucleoside Triphosphate, dMDATP, and its Enzymatic Incorporation into DNA
    Bioorg. Med. Chem. 2004, 12 (22), 5875-5880.
  • # Saito, Y.; Kanatani, K.; Ochi, Y.; Okamoto, A.; Saito, I.
    Design of base-discriminating fluorescent (BDF) nucleobase for SNP typing
    Nucleic Acids Symp. Ser. 2004, 48, 243-244.
  • # Okamoto, A.; Nishiza, K.-i.; Saito, I.
    Synthesis and Fluorescence Properties of Oligonucleotides Containing Pyrene-dimethylaniline Chromophore
    Nucleic Acids Symp. Ser. 2004, 48, 91-92.
  • # Ochi, Y.; Okamoto, A.; Saito, I.
    Fluorescent Probe for the Detection of DNA Conformational Transition
    Nucleic Acids Symp. Ser. 2004, 48, 73-74.
  • # Okamoto, A.; Kamei, T.; Tanaka, K.; Saito, I.
    Electrochemical Behavior of Gold Electrodes Modified with Photosensitizer-tethered DNA
    Nucleic Acids Symp. Ser. 2004, 48, 71-72.
  • # Tainaka, K.; Okamoto, A.; Saito, I.
    Development of a Novel Solvatochromic Pyrimidine Analog for Probing Local Dielectric Environment of DNA polymerase
    Nucleic Acids Symp. Ser. 2004, 48, 31-32.
  • Okamoto, A.; Tanaka, K.; Saito, I.
    DNA Logic Gates
    J. Am. Chem. Soc. 2004, 126 (30), 9458-9463.
  • Saito, Y.; Miyauchi, Y.; Okamoto, A.; Saito, I.
    Base-Discriminating Fluorescent (BDF) Nucleoside: Distinction of Thymine by Fluorescence Quenching
    Chem. Commun. 2004, (15), 1704-1705.
  • Okamoto, A.; Kanatani, K.; Ochi, Y.; Saito, Y.; Saito, I.
    A novel fluorescent guanine derivative distinguishable of three structures, single strand, duplex, and quadruplex
    Tetrahedron Lett. 2004, 45 (31), 6059-6062.
  • Okamoto, A.; Ichiba, T.; Saito, I.
    Pyrene-labeled Oligodeoxynucleotide Probe for Detecting Base Insertion by Excimer Fluorescence Emission
    J. Am. Chem. Soc. 2004, 126 (27), 8364-8365.
  • Okamoto, A.; Tanaka, K.; Fukuta, T.; Saito, I.
    Cytosine Detection by a Fluorescein-labeled Probe Containing Base-discriminating Fluorescent Nucleobase
    ChemBioChem 2004, 5 (7), 958-963.
  • Okamoto, A.; Inasaki, T.; Saito, I.
    Nitroxide-Labeled Guanine as an ESR Spin Probe for Structural Study of DNA
    Bioorg. Med. Chem. Lett. 2004, 14 (13), 3415-3418.
  • Okamoto, A.; Kanatani, K.; Saito, I.
    Pyrene-labeled Base-discriminating Fluorescent DNA Probes for Homogeneous SNP Typing
    J. Am. Chem. Soc. 2004, 126 (15), 4820-4827.
  • Okamoto, A.; Tanaka, K.; Saito, I.
    A nucleobase that releases reporter tags upon DNA oxidation
    J. Am. Chem. Soc. 2004, 126 (2), 416-417.
  • Tanabe, K.; Nakata, H.; Okamoto, A.; Saito, I.; Nishimoto, S.-i.
    Modulation of Photo-triggered Drug Release by Molecular Beacon Strategy
    Photomed. Photobiol. 2003, 25, 41-42.
  • Okamoto, A.; Tainaka, K.; Saito, I.
    Synthesis and Properties of Oligodeoxynucleotides Containing the Base-discriminating Fluorescent Nucleobase Benzopyridopyrimidine
    Photomed. Photobiol. 2003, 25, 39-40.
  • Okamoto, A.; Tainaka, K.; Saito, I.
    Synthesis and properties of a novel fluorescent nucleobase, naphthopyridopyrimidine
    Tetrahedron Lett. 2003, 44 (36), 6871-6874.
  • Okamoto, A.; Tanaka, K.; Fukuta, T.; Saito, I.
    Design of Base-discriminating Fluorescent Nucleoside and its Application to T/C SNP Typing
    J. Am. Chem. Soc. 2003, 125 (31), 9296-9297.
  • Okamoto, A.; Tainaka, K.; Saito, I.
    Detection of A/G Single Nucleotide Alteration in RNA Using Base-discriminating Fluorescent Oligodeoxynucleotides
    Chem. Lett. 2003, 32 (8), 684-685.
  • # Tanaka, K.; Okamoto, A.; Saito, I.
    Clear Distinction of Pyrimidine Bases on the Complementary Strand by Fluorescence Change of Novel Fluorescent Nucleosides
    Nucleic Acids Res. Supplement 2003, 3, 171-172.
  • # Kanatani, K.; Ochi, Y.; Okamoto, A.; Saito, I.
    DNA nanomotor using duplex-quadruplex conformational transition
    Nucleic Acids Res. Supplement 2003, 3, 161-162.
  • # Tanaka, K.; Okamoto, A.; Saito, I.
    Development of the Drug Release System in Hole Transfer Reaction through DNA
    Nucleic Acids Res. Supplement 2003, 3, 153-154.
  • # Tanaka, K.; Nishiza, K.-i.; Okamoto, A.; Saito, I.
    Enzymatic Ligation and Extension of DNA Wire
    Nucleic Acids Res. Supplement 2003, 3, 39-40.
  • Okamoto, A.; Tanabe, K.; Saito, I.
    P-loop Catalytically Assisting the Enzymatic Cleavage of Single-stranded DNA
    Bioorg. Med. Chem. 2003, 11 (17), 3747-3751.
  • Okamoto, A.; Tanabe, K.; Inasaki, T.; Saito, I.
    Phototriggered Drug Release from Functionalized Oligonucleotides by a Molecular Beacon Strategy
    Angew. Chem. 2003, 115 (22), 2606-2608; Angew. Chem., Int. Ed. 2003, 42 (22), 2502-2504.
  • Okamoto, A.; Tanaka, K.; Saito, I.
    Rational Design of a DNA Wire Possessing an Extremely High Hole Transport Ability
    J. Am. Chem. Soc. 2003, 125 (17), 5066-5071.
  • Okamoto, A.; Tainaka, K.; Saito, I.
    Clear Distinction of Purine Bases on the Complementary Strand by a Fluorescence Change of a Novel Fluorescent Nucleoside
    J. Am. Chem. Soc. 2003, 125 (17), 4972-4973.
  • Okamoto, A.; Kanatani, K.; Taiji, T.; Saito, I.
    15N-NMR Study on Site-Selective Binding of Metal Ions to Guanine Runs in DNA: A Good Correlation with HOMO Distribution
    J. Am. Chem. Soc. 2003, 125 (5), 1172-1173.
  • Tanabe, K.; Okamoto, A.; Nishimoto, S.-i.; Saito, I.
    Discrimination between cytosine and 5-methylcytosine in DNA by peptide nucleic acids
    Photomed. Photobiol. 2002, 24, 57-58.
  • Okamoto, A.; Tanaka, K.; Saito, I.
    Unique Hole-trapping Property of the Degenerate Base, 2-Amino-7-deazaadenine
    Bioorg. Med. Chem. Lett. 2002, 12 (24), 3641-3643.
  • # Tanabe, K.; Inasaki, T.; Okamoto, A.; Nishimoto, S.; Saito, I.
    Control of photo-induced drug release by the use of conformational change of DNA
    Nucleic Acids Res. Supplement 2002, 2, 167-168.
  • # Okamoto, A.; Kanatani, K.; Saito, I.
    Development of electrochemically gene-analyzing method using DNA-modified electrode
    Nucleic Acids Res. Supplement 2002, 2, 171-172.
  • Okamoto, A.; Tanabe, K.; Saito, I.
    Site-Specific Discrimination of Cytosine and 5-Methylcytosine in Duplex DNA by Peptide Nucleic Acids (PNA)
    J. Am. Chem. Soc. 2002, 124 (35), 10262-10263.
  • Okamoto, A.; Taiji, T.; Tainaka, K.; Saito, I.
    Oligonucleotides containing 7-vinyl-7-deazaguanine as a facile strategy for expanding the functional diversity of DNA
    Bioorg. Med. Chem. Lett. 2002, 12 (15), 1895-1896.
  • Okamoto, A.; Tainaka, K.; Saito, I.
    A facile incorporation of aldehyde function into DNA: 3-Formylindole nucleoside as an aldehyde-containing universal nucleoside
    Tetrahedron Lett. 2002, 43 (26), 4581-4583.
  • Okamoto, A.; Tanabe, K.; Dohno, C.; Saito, I.
    Modulation of remote DNA oxidation by hybridization with peptide nucleic acids (PNA)
    Bioorg. Med. Chem. 2002, 10 (3), 713-718.
  • Okamoto, A.; Tanaka, K.; Saito, I.
    2-Amino-7-deazaadenine forms stable base pairs with cytosine and thymine
    Bioorg. Med. Chem. Lett. 2002, 12 (1), 97-99.
  • Okamoto, A.; Tanabe, K.; Tanaka, K.; Saito, I.
    Control of hole migration in DNA for functionalized DNA wire
    Polym. Prep. Jpn. 2001, 50, 3790-3791.
  • Okamoto, A.; Tanabe, K.; Saito, I.
    Synthesis and properties of peptide nucleic acids containing psoralen unit
    Org. Lett. 2001, 3 (6), 925-927.
  • Okamoto, A.; Taiji, T.; Tanaka, K.; Saito, I.
    Synthesis and duplex stability of oligonucleotides containing 7-vinyl-7-deazaguanine as a strong electron-donating nucleobase
    Tetrahedron Lett. 2000, 41, 10035-10039.
  • # Tanabe, K.; Yoshida, K.; Dohno, C.; Okamoto, A.; Saito, I.
    Control of electron transfer in DNA by peptide nucleic acids (PNA)
    Nucleic Acids Symp. Ser. 2000, 44, 35-36.
  • Okamoto, A.; Nakamura, T.; Yoshida, K.; Nakatani, K.; Saito, I.
    Site-selective DNA alkylation of GG steps by naphthaldiimide derivatives possessing enantiomeric epoxide
    Org. Lett. 2000, 2 (21), 3249-3251.
  • Nakatani, K.; Okamoto, A.; Saito, I.
    Specific alkylation of guanine opposite to a single nucleotide bulge: A chemical probe for bulged structure of DNA
    Angew. Chem. 1999, 111, 3581-3584; Angew. Chem., Int. Ed. 1999, 38, 3378-3381.
  • Nakatani, K.; Okamoto, A.; Matsuno, T.; Saito, I.
    Highly selective DNA alkylation at the 5′-side G of a 5’GG3′ sequence by an aglycon model of pluramycin antibiotics through preferential intercalation into the GG step
    J. Am. Chem. Soc. 1998, 120, 11219-11225.
  • Nakatani, K.; Okamoto, A.; Saito, I.
    Synthesis of ABC ring analog of kapurimycin A3 as an effective DNA alkylating agent
    Angew. Chem. 1997, 109, 2881-2884; Angew. Chem., Int. Ed. 1997, 36, 2794-2797.
  • # Okamoto, A.; Nakatani, K.; Saito, I.
    Studies on the mechanism of DNA sequence selective alkylation by kapurimycin A3 analogs
    Nucleic Acids Symp. Ser. 1997, 37, 27-28.
  • # Nakatani, K.; Okamoto, A.; Okuda, S.; Saito, I.
    Truncated analogs of kapurimycin A3 and their DNA alkylation mechanism
    Nucleic Acids Symp. Ser. 1996, 35, 83-84.
  • Nakatani, K.; Okamoto, A.; Saito, I.
    6-Endo– and 5-exo-digonal cyclizations of o-hydroxyphenyl ethynyl ketones: A key step for highly selective benzopyranone formation
    Tetrahedron 1996, 52, 9427-9446.
  • Nakatani, K.; Okamoto, A.; Yamanuki, M.; Saito, I.
    Highly efficient synthesis of 2-substituted 4H-chromen-4-ones by means of F-induced 6-endo-digonal cyclization of o-(silyloxy)phenyl ethynyl ketone derivatives
    J. Org. Chem. 1994, 59, 4360-4361.

# = Proceedings of (International) Nucleic Acids Chemistry Symposium